Chao-Pin Hsiao, PhD, RN

Chao-Pin Hsiao.

Contact

Email: cxh416@case.edu

Phone: 216.368.3343

 

Assistant Professor

Research Interests

  • Molecular-Genetic Mechanisms of cancer-related fatigue
  • Changes in expression of genes related to mitochondrial function and fatigue in patients with prostate cancer receiving localized radiation therapy
  • Stress responses, symptoms, symptom distress, and symptom self-management in localized prostate cancer

Ongoing Research Projects

Mitochondrial Bioenergetic Mechanism of Cancer Related Fatigue

Principal Investigator: Chao-Pin Hsiao, PhD, RN

Funding Agency: NIH, National Institute of Nursing Research (K01)

Period: 08/2015-05/2018

  • This study examine the association among certain genes, mitochondrial bioenergetics, and fatigue in prostate cancer patients receiving localized radiation therapy over a period of time and to compare differences in gene expression, the mitochondrial bioenergetics profile, and fatigue between the patients with radiation therapy and without radiation therapy (on active surveillance).

Mitochondrial Bioenergetic Mechanism and  Cancer Related Fatigue in prostate Cancer: Bridge the Essential Knowledge and Skills of Mitochondrial Bioenergetics

Principal Investigator: Chao-Pin Hsiao, PhD, RN

Funding Agency: ACES+ ADVANCE Opportunity Grant, Case Western Reserve University

Period: 03/2016-03/2017

  • This grant supports travel to another facility to obtain essential and advanced training program in mitochondrial metabolism and bioenergetics, developing successful competitive research proposals integrating bench science, clinical practice, and novel interventions, stemming from a molecular-genetics perspective of symptom management in cancer.

Completed Research Projects

Changes in Mitochondrial Bioenergetics and Cancer-Related Fatigue in Prostate Cancer

Principal Investigator: Chao-Pin Hsiao, PhD, RN

Funding Agency: Oncology Nursing Society Foundation (RE01)

Period: 01/2014-01/2016

  • This is a pilot study exploring mitochondrial functions and fatigue experience in patients receiving localized radiation therapy. It focuses on establishing laboratory procedures and baseline data.

Relationship between Mitochondrial Dysfunction and Fatigue in Cancer Patients Following External Beam Radiation Therapy

Principal Investigator: Chao-Pin Hsiao, PhD, RN

Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program

Period: 05/2009-01/2014

  • (10-NR-0088) This study explored changes in the expression of mitochondrial genes that are associated with fatigue symptoms of prostate cancerpatients receiving localized radiation therapy.

Investigating Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy

Role: Lead Associate Investigator                 

Principal Investigator: L. Saligan, PhD, RN, FAAN

Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program

Period: 05/2010-01/2014

  • (10-NR-0088) This study explored explores the molecular-genetic mechanisms underlying fatigue and the cluster of symptoms (urinary, sexual, gastrointestinal, and psychiatric) experienced by prostate cancer patients undergoing External Beam Radiation Therapy (EBRT).

Investigating Correlates of Fatigue in Cancer Patients Receiving Treatment

Principal Investigator: Chao-Pin Hsiao, PhD, RN

Funding Agency: NIH, National Institute of Nursing Research, Intramural Research Program

Period: 06/2011-01/2014

  • (10-NR-0014) This study explored explores the molecular-genetic mechanisms underlying fatigue experienced by cancer patients receiving various therapies (e.g. immune therapy, hormone therapy, and chemotherapy).

Education Interests

  • Translational Research
  • Symptom Management
  • Oncology Nursing

Educational Background

  • BSN, Nursing, National Taiwan University, School of Nursing, Taipei, Taiwan
  • MSN, Oncology Nursing, National Taiwan University, School of Nursing, Taipei, Taiwan
  • PhD, Injury Mechanisms and Biobehavior, University of Arizona, School of Nursing, Tucson, Ariz.
  • Post-Doc, National Institutes of Health, National Institute of Nursing Research, Symptom Biology Unit, Bethesda, Md.

Recent Publications

  • Hsiao, C.-P., Daly, B., & Saligan, L. (2016). The Etiology and management of radiotherapy-induced fatigue. Expert Review of Quality of Life in Cancer Care, 1(4), 323-328
  • Kelly DL, Dickinson K, Hsiao C-P, Lukkahatai N, Gonzalez-Marrero V, McCabe M, Saligan LN (2016). Biological Basis for the Clustering of Symptoms, Seminars in Oncology Nursing, doi:10.1016/j.soncn.2016.08.002
  • Hsiao, C.P., Daly, B., & Hoppel, C. (2015).  Association between Mitochondrial Bioenergetics and Radiation-related Fatigue: A Possible Mechanism and Novel Target. The Journal of Archieves in Cancer Research, 3 (2), 1-9
  • Hsiao, C.P., Araneta, M., Reddy, S.Y., Chen, M.-K., & Saligan, L. (2015).  Genomic Profile of Fatigued Men While receiving Localized Radiation Therapy. The Journal of Biological Research for Nursing.
  • Feng, R., Chen, M.-K., Lukkahatai N, Hsiao, C.P., Kaushal, A., Lee Sechrest & Saligan, L. (2015).  Clinical predictors of fatigue in non-metastatic prostate cancer patients receiving external beam radiation therapy. Journal of Clinical Oncology Nursing, 19 (6), 744-750
  • Hsiao, C.P., Wang, D., Kaushal, A., Chen, M.-K., & Saligan, L. (2014).  Differential Expression of Genes Related to Mitochondrial Biogenesis and Bioenergetics in Fatigued Prostate Cancer Men Receiving External Beam Radiation Therapy. Journal of Pain and Symptom Management, 48 (6), 1080-90.
  • Lukkahatai N, Patel S, Gucek M, Hsiao C.P., Saligan LN. (2014). Proteomic Serum Profile of Fatigued Men Receiving Localized External Beam Radiation Therapy for Non-Metastatic Prostate Cancer. J Pain Symptom Manage, 47 (4), 748-56.
  • Hsiao, C. P., Moore, I. M. (Ki), Insel, K.C. & Merkle, C. (2014). Symptom Self-Management Strategies in Localized Prostate Cancer. Journal of Clinical Nursing, 23 (3-4), 440-9.
  • Hsiao, C.P., Araneta, M., Wang, X-M., Saligan, L. (2013). The association of IFI27 Expression and Fatigue Intensification during Localized Radiation Therapy: Implication of a Para-Inflammatory Bystander Response. International Journal of Molecular Science, 14 (8), 19643-57.
  • Hsiao, C.P., Wang, D., Kaushal, A., Saligan, L. (2013). Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam readiation therapy. Cancer Nusingr, 36 (3), 189-97.
  • Saligan LN, Hsiao C.P., Wang D, Wang X, Kaushal A, Citrin D, Barb JJ, Munson PJ, Dionne RA. (2012). Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways. Brain, Behavior, and Immunity, 27 (1), 63-70.
  • Insel, K.C., Merkle, C. J., Hsiao, C.P., Vidrine, A.N., & Montgomery, D.W. (2012). Biomarkers for Cognitive Aging--Part I: Telomere Length, Blood Pressure and Cognition Among Individuals With Hypertension. Biological Research for Nursing, 14 (2), 124-32.
  • Hsiao, C. P., Moore, I. M. (Ki), Insel, K.C. & Merkle, C. (2011). High perceived stress is linked to afternoon cortisol levels and greater symptom distress in patients with Localized Prostate Cancer. Cancer Nursing, 34 (6), 470-78.

Accreditations and Awards

  • The Junior Research Researcher Award, Midwest Nursing Research Society
  • Member, Midwest Nursing Research Society (MNRS), 2013-present
  • Member, Oncology Nursing Society, 2003 – present
  • Member, Sigma Theta Tau, Beta Mu Chapter 2003 – present
  • Member, International Sigma Theta Tau, 1999 – present